MEPISAN (mepyramine maleate) cream is indicated for the relief of itching associated with allergic skin conditions, contraindicated in individuals with a known hypersensitivity to mepyramine or any other components of the formulation, may cause side effects such as local irritation, dryness, or allergic reactions, and may interact with other antihistamines or central nervous system depressants, potentially enhancing their sedative effects.